EpiScreen Plus

Neutral Alpha-Glucosidase determination

The bulk of the alpha-glucosidase activity in semen, and more particular that of its neutral iso-enzyme (NAG), depends on secretion by the epididymis. In patients with azoospermia and normal androgen levels in peripheral blood, NAG activity in semen plasma is a reliable marker of the epididymal contribution to the ejaculate.

Low NAG activity in seminal plasma of patients with oligozoospermia may reflect partial obstruction of the epididymides, associated with infections or inflammatory disease. Enzyme activity in patients with normal sperm concentration is correlated with the result of the Shorr-stain of midpiece and tail, reflecting changes in cell membrane, induced by epididymal secretion. The EpiScreen Plus assay may assist in the diagnosis and the management of male infertility.

EpiScreen Plus has a 24 month shelf life from production date. Information about the composition of the product can be found in the material safety data sheet.

Regulatory

Europe: CE-marked – Australia: registered

Product order code

EPI_PLUS : EpiScreen Plus kit – 25 tests

Product literature

Abdella A.M., Omer A.E., Al-Aabed B.H., Biochemical markers in semen and their correlation with fertility hormones and semen quality among Sudanese infertile patients, African Journal of Biochemistry Research (2010),Vol.4,No.11,pp.255-260

Azenabor, A.; Ezeafulukwe J.; Ekun A.O.; Bamiro B.S. , Seminal plasma levels of neutral alpha glucosidase activity and its interactions with spermiogram in Nigerian males, Annual Research & Review in Biology (2016),Vol.9,No.4,pp.1-7

Batou A.S., Ovono Abessolo F., Mba I., Mintsa A. , Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville, Int. J. Biol. Chem. Sci. (2018),Vol.12,No.6,pp.2486-2502

Eertmans, F.; Bogaert, V.; Van Poecke, T.; Puype, B, An Improved Neutral a-Glucosidase Assay for Assessment of Epididymal Function – Validation and Comparison to the WHO Method, Diagnostics (2014),Vol.4,pp.1-11

Goss D.M., Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions, Doctoral dissertation, Stellenbosch: Stellenbosch University (2018),Vol.0

Silva, J.V.; Cruz, D.; Gomes, M., et al. , Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality, Sci Rep (2017),Vol.7,No.45457

Frequently Asked Questions Certificate Of Analysis

In patients with azoospermia and normal androgen levels in peripheral blood, NAG activity in semen plasma is a reliable marker of the epididymal contribution to the ejaculate

Instructions For Use

Material Safety Data Sheet

Calculation sheet EpiScreen Plus

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