EpiScreen Plus

Neutral Alpha-Glucosidase determination

EpiScreen Plus™ can be used to determine the neutral alpha-glucosidase activity in semen (plasma), an enzyme which is mainly secreted by the epididymis. The activity of this enzyme is a reliable marker for epididymis function in patients with (very) low sperm concentration or azoospermic patients, having a normal androgen blood level:

  • very low activity indicates a bilateral obstruction between the epididymis and the ejaculatory duct.
  • low activity may reflect partial obstruction of the epididymis.
  • normal enzyme activity is expected when there is an obstruction above the area in which the enzyme is secreted or in cases of non-obstructive azoospermia (testicular disfunction).

EpiScreen Plus™ is a semi-quantitative, non-automated, photometric and diagnostic kit for detecting neutral alpha-glucosidase in human semen or seminal plasma and may be useful for the diagnosis and the management of male infertility.

EpiScreen Plus has a 24 month shelf life from production date. Information about the composition of the product can be found in the material safety data sheet.

Regulatory

Europe: CE-marked (IVDR, Notified Body number 2797) – Australia: registered – Other regions: available upon request

Product order code

EPI_PLUS : EpiScreen Plus kit – 25 tests

Abdella A.M., Omer A.E., Al-Aabed B.H., Biochemical markers in semen and their correlation with fertility hormones and semen quality among Sudanese infertile patients, African Journal of Biochemistry Research (2010),Vol.4,No.11,pp.255-260

Azenabor, A.; Ezeafulukwe J.; Ekun A.O.; Bamiro B.S. , Seminal plasma levels of neutral alpha glucosidase activity and its interactions with spermiogram in Nigerian males, Annual Research & Review in Biology (2016),Vol.9,No.4,pp.1-7

Batou A.S., Ovono Abessolo F., Mba I., Mintsa A. , Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville, Int. J. Biol. Chem. Sci. (2018),Vol.12,No.6,pp.2486-2502

Eertmans, F.; Bogaert, V.; Van Poecke, T.; Puype, B, An Improved Neutral a-Glucosidase Assay for Assessment of Epididymal Function – Validation and Comparison to the WHO Method, Diagnostics (2014),Vol.4,pp.1-11

Goss D.M., Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions, Doctoral dissertation, Stellenbosch: Stellenbosch University (2018),Vol.0

Silva, J.V.; Cruz, D.; Gomes, M., et al. , Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality, Sci Rep (2017),Vol.7,No.45457

In patients with azoospermia and normal androgen levels in peripheral blood, NAG activity in semen plasma is a reliable marker of the epididymal contribution to the ejaculate

Instructions For Use
Material Safety Data Sheet
Calculation sheet EpiScreen Plus