SpermMar™ IgA

Test for the detection of anti-sperm antibodies

SpermMar™ IgA and SpermMar™ IgG are rapid, easy-to-use tests for the detection of anti-sperm antibodies in semen and serum.
Anti sperm antibodies (ASA) are produced when the blood-testis barrier is disrupted by obstruction, infection or traumatism. Immunoglobulines of the IgG class are usually present in both serum and semen, and the IgG antibodies attach to the spermatozoa. ASA of the IgA class are secreted by the accessory sex glands and are found in semen only. ASA of the IgG class may be detected in seminal plasma, but there is usually no free IgA in seminal plasma. Anti sperm antibodies of the IgA class almost never occur without IgG antibodies.
In case more than 40% of motile spermatozoa present ASA of the IgG class, complementary testing for IgA antibodies is advisable.
The immunological factor reduces the probability of spontaneous conception, and this is particularly true when ASA of the IgA class are also present.

SpermMar™ IgA has a 12 month shelf life from date of produce.

We recommend to watch our demonstration video of the SpermMar Test IgA:


Europe: CE-marked - USA: registered - Canada: Health Canada licence
Brazil: registered - Australia: registered

Product order codes

SPMA_S SpermMar IgA singles - 50 tests
SPMA_C SpermMar IgA complete - 50 tests


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Marconi M., Nowotny A., Pantke P., Diemer T., Weidner W., Antisperm antibodies detected by mixed agglutination reaction and immunobead test are not associated with chronic inflammation and infection of the seminal tract, Andrologia (2008),Vol.40,pp.227-234

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Nikolaeva M.A., Balyasnikova I.V., Alexinskaya M.A., Metzger R., Franke E., Albrecht R.F. , Kulakov V.I., Sukhikh G.T., Danilov S.M, Testicular Isoform of Angiotensin I-Converting Enzyme (ACE, CD143) on the Surface of Human Spermatozoa: Revelation and Quantification Using Monoclonal Antibodies, American Journal of Reproductive Immunology (2006),Vol.55,pp.25-68

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Bohring C., Klepper L., Krause W., Localization of binding sites of naturally occurring antisperm antibodies on human spermatozoa by immunofluorescence, Andrologia (2004),Vol.36,pp.286-290

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Bohring C., Krause W., Characterization of Spermatozoa Surface Antigens by Antisperm Antibodies and its Influence on Acrosomal Exocytosis, American Journal of Reproductive Immunology (2003),Vol.50,pp.411-419

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Chiu W.W-C., Chamley L.W., Human seminal plasma prolactin-inducible protein is an immunoglobulin G-binding protein, Journal of Reproductive Immunology (2003),Vol.60,pp.97-111

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Tomsu M., Sharma V., Miller D., Embryo quality and IVF treatment outcomes may correlate with different sperm comet assay parameters, Human Reproduction (2002),Vol.17,No.7,pp.1856-1862

Lombardo F., Gandini L., Dondero F., Lenzi A., Immunology and immunopathology of the male genital tract. Antisperm immunity in natural and assisted reproduction, Human Reproduction Update (2001),Vol.7,No.5,pp.450-456

Bohring C., Krause E., Habermann B., Krause W., Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease, Molecular Human Reproduction (2001),Vol.7,No.2,pp.113-118

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Depuydt C.E., De Potter C.R., Zalata A., Baekelandt E., Bosmans E., Comhaire F.H., Levels of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) in Seminal Plasma of Patients With Andrological Diseases, Journal of Andrology (1998),Vol.19,No.2,pp.175-182

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Verheyen G., Tournaye H., Laurier K., Devroey P., Van Steirteghem A., Auto-controlled study on in-vitro fertilization performance with 'antibody-free' spermatozoa selected by immunobead adsorption from semen of patients with anti-sperm antibodies, Human Reproduction (1994),Vol.9,No.6,pp.1119-1126

Lähteenmäki A., In-vitro fertilization in the presence of antisperm antibodies detected by the mixed antiglobulin reaction (MAR) and the tray agglutination test (TAT), Human Reproduction (1993),Vol.8,No.1,pp.84-88

Rasanen M.L., Havatta O.L., Penttila I.M., Agrawal Y.P., Detection and Quantitation of Sperm-Bound Antibodies by Flow Cytometry of Human Semen, Journal of Andrology (1992),Vol.13,No.1,pp.55-64

Rajah S.V., Parslow J.M., Howell R.J.S., Hendry W.F., Comparison of mixed antglobulin reaction and direct immunobead test for detection of sperm-bound antibodies in subfertile males, Fertility and Sterility (1992),Vol.57,No.6,pp.1300-1303

Kay D.J., Boettcher B., Comparison of the SpermMar Test with Currently Accepted Procedures for Detecting Human Sperm Antibodies, Reprod. Fertil. Dev. (1992),Vol.4,pp.175-81

Hinting A., Vermeulen L., Comhaire H.H., The indirect mixed antiglobulin reaction test using a commercially available kit for the detection of antisperm antibodies in serum, Fertility and Sterility (1988),Vol.49,No.6,pp.1039-1044


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